Based on NCCPA blueprint weightings, the highest-frequency organ systems on the PANCE are: Cardiology (~16%), Pulmonology (~12%), Musculoskeletal (~10%), and GI/Nutrition (~9%). Within these, high-yield topics include: ACS/MI management, heart failure, COPD vs asthma exacerbation, pneumonia types, osteoarthritis vs RA, IBD (Crohn's vs UC), and peptic ulcer disease. For task areas, 'Applying Foundational Science Concepts' and 'Formulating Most Likely Diagnosis' together account for over 50% of questions. BlitzGrok practice questions are tagged by organ system, task area, and difficulty level so you can build a targeted study plan.